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KMID : 0386520160250010133
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Research Institute of Korean Medicone
2016 Volume.25 No. 1 p.133 ~ p.144
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Anti-dyslipidemic Effect of ACLL extract (Artemisia capillaris Thunb, Curcuma longa L, Lycium chinense, Ligustrum lucidum Aiton complex extract) on High Cholesterol Diet-induced Dyslipidemia in Mice
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Kim Tae-Youn
Oh Jeong-Min
Kim Yoon-Sik
Jo Hyun-Kyung
Yoo Ho-Ryong
Seol In-Chan
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Abstract
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Objectives : This study was aimed to investigate the effect of ACLL extract (Artemisia capillaris Thunb, Curcuma longa L, Lycium chinense, Ligustrum lucidum Aiton complex extract) in a dyslipidemia animal model induced by a high-fat diet.
Methods : ACLL extracts was administered at 200 mg/kg, and 400 mg/kg to Apoe mice, where arthritis was induced by high cholesterol diet. After mice were treated with GO for 4 weeks, we measured AST, ALT, BUN and lipid levels (total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride), atherogenic index(AI) and cardiac risk factor(CRF).
Results : Serum AST, ALT, creatinine, BUN levels were not changed by ACLL extract do not show any toxic effects. Also, ACLL extract groups were found to have atherogenic Index and cardiac risk factor as well as lipid metabolism improvement (total cholesterol, LDL cholesterol and triglyceride decrease).
Conclusions : We suggest that ACLL extract may have the control effects of Dyslipidemia by improving lipid metabolism.
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KEYWORD
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ACLL , ApoE-konckout mouse , Dyslipidemia , High fat diet , Hyperlipidemic , lipid metabolism
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